Research on theprotein REST makes it much easier to generate proteins with the right properties for
Researchers find that the activity of the nervous system may influence human longevity. Neural excitation linked to shorter life, while suppression of overactivity appears to extend life span. Protein REST, previously shown to protect aging brains from age-related
Researchers discover that the activity of the nervous system may influence human longevity. Neural excitation linked to shorter life, while suppression of overactivity appears to extend life span. Protein REST, previously shown to protect aging brains from age-related dementia and Alzheimer’s. For the first time humans and other vertebrates have been shown to have a genetic activity which is positively correlated to the lifespan of the organisma
Research leads to a more refined and accurate genetic marker for Alzheimer’s, as revealed in a new study funded by the National Institutes of Health. A combination of genetically determined and observed behaviors in mice and worms, as well as the presence of a specific aminoacid in the same molecule, can be used as a better predictor for Alzheimer’s (AD). The study demonstrates the potential of such biomarkers in the treatment and prediction of AD in humans, and…
Alzheimer’s and dementia are growing epidemic-threatening disorders, and in the United States more are diagnosed every year than a hundred years ago because of the growing number of elderly patients and the rising cost of care. However, there are only a few known therapeutics and therapies that offer promise for slow or stop the progression or cure in some of these diseases. Genetic algorithms, however, have become
In this latest article I will describe the new research from the Department of Psychiatry and Behavioral Sciences at The University of Texas MD Anderson Cancer Center (MDAC) in Houston. We discuss the latest research published in the July 14, 2015 issue of the journal Cell that shows Alzheimer’s and early dementia are genetically linked, and suggest new strategies to predict the risk of developing or suffering from both disorders.
The majority of Alzheimer’s disease patients begin to appear at a younger age and are typically diagnosed in their 30s. However, the risk for developing early dementia can be quite high at a young age. Researchers from MDAC have identified a gene called RANKL that predicts the onset of Alzheimer’s and dementia. The current study shows that a deficiency in one of the RANKL enzymes called beta-amyloid peptides (or BAPs) can result in accelerated Alzheimer’s disease progression. The beta-amyloid peptides are highly amyloidogenic proteins that disrupt protein folding in the brain as we age.
The article discusses the new research published from the Department of Psychiatry and Behavioral Sciences at The University of Texas MD Anderson Cancer Center (MDAC). This study shows that the activity level of opioid receptors is increased and their presence correlates with the incidence of Alzheimer’s (AD). The RANKL-1 gene was found to have an association with opioid receptors along with other genes that have already been shown to positively correlate with the risk of Alzheimer’s disease, such as AD.
The current article discusses a new study published in the October 15, 2015 issue of the Proceedings of the National Academy of Sciences by the Center for Biomedical Informatics, National Institutes of Health (NIH), in collaboration with researchers at The University of Texas MD Anderson Cancer Center (MDAC). The new findings describe a mechanism by which a particular enzyme is involved in insulin resistance in beta-amyloid precursor protein (APP). This result suggests that -amyloid production may act in an inhibitory way by activating insulin resistance.